Patrick J Brennan Selected Research

Thioacetazone (Thiacetazone)

2/2015	Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone.
11/2012	A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone.

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Patrick J Brennan Research Topics

Disease

37	Leprosy (Hansen's Disease) 01/2021 - 05/2002
35	Tuberculosis (Tuberculoses) 02/2015 - 03/2002
22	Infections 06/2022 - 07/2002
5	Lepromatous Leprosy 02/2013 - 03/2005
4	Neoplasms (Cancer) 08/2019 - 06/2007
3	Surgical Wound Infection 02/2011 - 03/2003
2	COVID-19 06/2022 - 01/2020
2	Inflammation (Inflammations) 12/2019 - 01/2017
2	Multibacillary Leprosy 12/2012 - 09/2005
2	Urinary Tract Infections (Urinary Tract Infection) 02/2011 - 05/2010
2	Sepsis (Septicemia) 02/2011 - 05/2005
2	Coinfection 01/2009 - 01/2009
2	Paucibacillary Leprosy 12/2005 - 09/2005
2	Pulmonary Tuberculosis 12/2004 - 03/2002
1	Postoperative Pain 03/2021
1	Pain (Aches) 03/2021
1	Mycobacterium Infections (Infections, Mycobacterium) 01/2021
1	red meat allergy 01/2020
1	Allergic Rhinitis 12/2019
1	Asthma (Bronchial Asthma) 12/2019
1	Pneumonia (Pneumonitis) 12/2019
1	Food Hypersensitivity (Food Allergy) 01/2018
1	HIV Infections (HIV Infection) 01/2018
1	Mycoses (Diseases, Fungus) 01/2016
1	Dehydration (Water Stress) 02/2015
1	Lymphoma (Lymphomas) 01/2014
1	Neglected Diseases 01/2014
1	Tuberculoid Leprosy 12/2012
1	Disease Progression 12/2012

Drug/Important Bio-Agent (IBA)

17	AntigensIBA 01/2016 - 03/2002
12	lipoarabinomannan (LAM)IBA 01/2018 - 05/2002
11	Proteins (Proteins, Gene)FDA Link 02/2013 - 07/2002
10	LipidsIBA 01/2017 - 03/2005
8	Pharmaceutical PreparationsIBA 01/2021 - 07/2002
8	EnzymesIBA 02/2015 - 03/2002
8	Peptides (Polypeptides)IBA 01/2012 - 07/2003
6	GlycolipidsIBA 01/2020 - 05/2004
6	Recombinant ProteinsIBA 02/2011 - 09/2005
5	CytokinesIBA 12/2019 - 03/2009
4	VaccinesIBA 06/2022 - 08/2002
4	Mycolic Acids (Mycolic Acid)IBA 11/2012 - 12/2003
4	MannosidesIBA 01/2009 - 05/2002
3	NucleotidesIBA 08/2019 - 09/2006
3	ProdrugsIBA 02/2015 - 08/2004
3	thiocarlideIBA 02/2015 - 11/2007
3	Tuberculin (PPD)IBA 01/2014 - 05/2007
3	Indicators and Reagents (Reagents)IBA 02/2013 - 12/2005
3	Glycoproteins (Glycoprotein)IBA 12/2011 - 07/2002
3	AntibodiesIBA 12/2011 - 05/2004
3	ImmunosorbentsIBA 09/2011 - 03/2002
3	lipomannanIBA 10/2010 - 05/2002
3	DNA (Deoxyribonucleic Acid)IBA 09/2009 - 09/2009
3	Interferon-gamma (Interferon, gamma)IBA 03/2009 - 09/2005
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2009 - 09/2003
3	GlycosyltransferasesIBA 09/2006 - 07/2002
2	Uridine Diphosphate (UDP)IBA 12/2019 - 12/2010
2	Polysaccharides (Glycans)IBA 01/2018 - 06/2007
2	LipopolysaccharidesIBA 01/2018 - 10/2010
2	Thioacetazone (Thiacetazone)IBA 02/2015 - 11/2012
2	Type II Fatty Acid SynthaseIBA 02/2015 - 11/2012
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2014 - 10/2011
2	Biomarkers (Surrogate Marker)IBA 12/2012 - 09/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2012 - 09/2003
2	Biological ProductsIBA 01/2012 - 09/2011
2	RNA (Ribonucleic Acid)IBA 01/2012 - 12/2006
2	EpitopesIBA 01/2012 - 06/2004
2	Human Serum Albumin FDA LinkGeneric 12/2011 - 06/2010
2	DisaccharidesIBA 12/2011 - 06/2010
2	Mycobacterium leprae phenolic glycolipid IIBA 12/2011 - 02/2011
2	Immunoglobulin M (IgM)IBA 12/2011 - 03/2002
2	AcidsIBA 07/2011 - 02/2011
2	Isoniazid (Ftivazide)FDA LinkGeneric 12/2009 - 08/2004
2	arabanIBA 11/2008 - 07/2006
2	SugarsIBA 06/2007 - 09/2006
1	BNT162 VaccineIBA 06/2022
1	Opioid Analgesics (Opioids)IBA 03/2021
1	Narcotics (Narcotic Analgesics)IBA 03/2021
1	CholesterolIBA 01/2021
1	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 12/2019
1	LeukotrienesIBA 12/2019
1	Interleukin-12 Subunit p40IBA 12/2019
1	purinoceptor P2Y6IBA 12/2019
1	arabinofuranoseIBA 01/2018
1	Monoclonal AntibodiesIBA 01/2018
1	SphingolipidsIBA 01/2018
1	tuberculostearic acidIBA 01/2018
1	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2016
1	Galactosylceramides (Galactocerebrosides)IBA 01/2014
1	LeprominIBA 01/2014
1	arabinogalactanIBA 11/2012
1	Hydro-Lyases (Dehydratases)IBA 11/2012
1	Protein Isoforms (Isoforms)IBA 08/2012
1	TrisaccharidesIBA 12/2011
1	Dapsone FDA Link 11/2011
1	Toll-Like Receptor AgonistsIBA 10/2011

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 12/2014 - 04/2004
3	Therapeutics 12/2015 - 07/2006
2	Catheters 02/2011 - 05/2010
1	Ambulatory Surgical Procedures (Outpatient Surgery) 03/2021
1	Mechanical Ventilators (Ventilator) 01/2020